Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine de...
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type efflux pumps is a major factor in multidrug resistance (MDR), which makes these pumps important antibacterial drug discovery targets. We have recently developed novel pyranop...
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Full title
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
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TN_cdi_jstor_primary_26468830
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26468830
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1602472113
