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Distinct recognition of complement iC3b by integrins αXβ₂ and αMβ

Distinct recognition of complement iC3b by integrins αXβ₂ and αMβ

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26480337

Distinct recognition of complement iC3b by integrins αXβ₂ and αMβ

About this item

Full title

Distinct recognition of complement iC3b by integrins αXβ₂ and αMβ

Publisher

National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (13), p.3403-3408

Language

English

Formats

Publication information

Publisher

National Academy of Sciences

More information

Scope and Contents

Contents

Recognition by the leukocyte integrins αXβ₂ and αMβ₂ of complement iC3b-opsonized targets is essential for effector functions including phagocytosis. The integrin-binding sites on iC3b remain incompletely characterized. Here, we describe negative-stain electron microscopy and biochemical studies of αXβ₂ and αMβ₂ in complex with iC3b. Despite high h...

Alternative Titles

Full title

Distinct recognition of complement iC3b by integrins αXβ₂ and αMβ

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_jstor_primary_26480337

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26480337

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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