Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex
Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. By using NMR spectroscopy and site-directed mutagenesis, we have mapped the binding...
Alternative Titles
Full title
Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex
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Record Identifier
TN_cdi_jstor_primary_3147471
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_3147471
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0836054100
