Phosphoprotein Inhibitor CPI-17 Specificity Depends on Allosteric Regulation of Protein Phosphatase-...
Phosphoprotein Inhibitor CPI-17 Specificity Depends on Allosteric Regulation of Protein Phosphatase-1 by Regulatory Subunits
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Inhibition of myosin phosphatase is critical for agonist-induced contractility of vascular smooth muscle. The protein CPI-17 is a phosphorylation-dependent inhibitor of myosin phosphatase and, in response to agonists, Thr-38 is phosphorylated by protein kinase C, producing a > 1,000-fold increase in inhibitory potency. Here, we addressed how CPI-17...
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Full title
Phosphoprotein Inhibitor CPI-17 Specificity Depends on Allosteric Regulation of Protein Phosphatase-1 by Regulatory Subunits
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TN_cdi_jstor_primary_3372359
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_3372359
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0307812101
