Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
About this item
Full title
Author / Creator
Artis, Dean R , Lin, Jack J , Zhang, Chao , Wang, Weiru , Mehra, Upasana , Perreault, Mylene , Erbe, David , Krupka, Heike I , England, Bruce P , Arnold, James , Plotnikov, Alexander N , Marimuthu, Adhirai , Nguyen, Hoa , Will, Sarah , Signaevsky, Maxime , Kral, John , Cantwell, John , Settachatgull, Calvin , Yan, Douglas S , Fong, Daniel , Oh, Angela , Shi, Shenghua , Womack, Patrick , Powell, Benjamin , Habets, Gaston , West, Brian L , Zhang, Kam Y.J , Milburn, Michael V , Vlasuk, George P , Hirth, K. Peter , Nolop, Keith , Bollag, Gideon , Ibrahim, Prabha N and Tobin, James F
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
In a search for more effective anti-diabetic treatment, we used a process coupling low-affinity biochemical screening with high-throughput co-crystallography in the design of a series of compounds that selectively modulate the activities of all three peroxisome proliferator-activated receptors (PPARs), PPARα, PPARγ, and PPARδ. Transcriptional trans...
Alternative Titles
Full title
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
Authors, Artists and Contributors
Author / Creator
Lin, Jack J
Zhang, Chao
Wang, Weiru
Mehra, Upasana
Perreault, Mylene
Erbe, David
Krupka, Heike I
England, Bruce P
Arnold, James
Plotnikov, Alexander N
Marimuthu, Adhirai
Nguyen, Hoa
Will, Sarah
Signaevsky, Maxime
Kral, John
Cantwell, John
Settachatgull, Calvin
Yan, Douglas S
Fong, Daniel
Oh, Angela
Shi, Shenghua
Womack, Patrick
Powell, Benjamin
Habets, Gaston
West, Brian L
Zhang, Kam Y.J
Milburn, Michael V
Vlasuk, George P
Hirth, K. Peter
Nolop, Keith
Bollag, Gideon
Ibrahim, Prabha N
Tobin, James F
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_jstor_primary_40272351
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_40272351
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0811325106
