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Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls Iymphoid follicle organi...

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls Iymphoid follicle organi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_41242288

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls Iymphoid follicle organization and germinal center reaction

About this item

Full title

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls Iymphoid follicle organization and germinal center reaction

Publisher

National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (19), p.7926-7931

Language

English

Formats

Publication information

Publisher

National Academy of Sciences

More information

Scope and Contents

Contents

Grb2 (growth-factor receptor-bound protein-2) is a signaling adaptor that interacts with numerous receptors and intracellular signaling molecules. However, its role in B-cell development and function remains unknown. Here we show that ablation of Grb2 in B cells results in enhanced B-cell receptor signaling; however, mutant B cells do not form germ...

Alternative Titles

Full title

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls Iymphoid follicle organization and germinal center reaction

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_jstor_primary_41242288

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_41242288

Other Identifiers

ISSN

0027-8424

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