Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Interleukin-1α (IL-1α) and -β both bind to the same IL-1 receptor (IL-1R) and are potent proinflammatory cytokines. Production of proinflammatory (pro)–IL-1α and pro–IL-1β is induced by Toll-like receptor (TLR)-mediated NF-κB activation. Additional stimulus involving activation of the inflammasome and caspase-1 is required for proteolytic cleavage...
Alternative Titles
Full title
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
Authors, Artists and Contributors
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Record Identifier
TN_cdi_jstor_primary_41352651
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_41352651
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1109176108
