Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and cleave the collagen triple helix is not fully understood. Here, we report temperature-dependent binding of a catalytically inactive MMP-1 mutant (E200A) to collagen through the cooperative action...
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Full title
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1
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Record Identifier
TN_cdi_jstor_primary_41685421
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_41685421
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1204991109
