Negamycin induces translational stalling and miscoding by binding to the small subunit head domain o...
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Significance The identification of negamycin’s binding site within helix 34 of the small subunit head domain and the elucidation of its mechanism of action during messenger RNA decoding provide a physical framework for exploring structure–activity relationships of this largely unexplored antibiotic class. These findings lay the foundation for the r...
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Full title
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome
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TN_cdi_jstor_primary_43190213
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_43190213
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1414401111
