Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of t...
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
About this item
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Author / Creator
Li, Guodong , Li, Dan , Wu, Chun , Li, Shengnan , Chen, Feng , Li, Peng , Ko, Chung-Nga , Wang, Wanhe , Lee, Simon Ming-Yuen , Lin, Ligen , Ma, Dik-Lung and Leung, Chung-Hang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α methylation and regulating the transcription of HIF-1α target genes, which are responsible for angiogenesis and wound healing. Here, we report the Ir(III) complex
Set7_1a
bearing acetonitrile (ACN) ligands as a SET7/9 methyltransferase inhibitor and HIF-1α stab...
Alternative Titles
Full title
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10031211
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10031211
Other Identifiers
ISSN
2092-6413,1226-3613
E-ISSN
2092-6413
DOI
10.1038/s12276-022-00804-1
