Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV
Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV
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Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Joyce, M Gordon , Zhang, Baoshan , Ou, Li , Chen, Man , Chuang, Gwo-Yu , Druz, Aliaksandr , Kong, Wing-Pui , Lai, Yen-Ting , Rundlet, Emily J , Tsybovsky, Yaroslav , Yang, Yongping , Georgiev, Ivelin S , Guttman, Miklos , Lees, Christopher R , Pancera, Marie , Sastry, Mallika , Soto, Cinque , Stewart-Jones, Guillaume B E , Thomas, Paul V , Van Galen, Joseph G , Baxa, Ulrich , Lee, Kelly K , Mascola, John R , Graham, Barney S and Kwong, Peter D
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
An interactive structure-based approach was used to improve a vaccine antigen against respiratory syncytium virus (RSV), thus leading to immunogens with higher stability that elicit higher neutralizing titers in mice.
Structure-based design of vaccines, particularly the iterative optimization used so successfully in the structure-based design of...
Alternative Titles
Full title
Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV
Authors, Artists and Contributors
Author / Creator
Joyce, M Gordon
Zhang, Baoshan
Ou, Li
Chen, Man
Chuang, Gwo-Yu
Druz, Aliaksandr
Kong, Wing-Pui
Lai, Yen-Ting
Rundlet, Emily J
Tsybovsky, Yaroslav
Yang, Yongping
Georgiev, Ivelin S
Guttman, Miklos
Lees, Christopher R
Pancera, Marie
Sastry, Mallika
Soto, Cinque
Stewart-Jones, Guillaume B E
Thomas, Paul V
Van Galen, Joseph G
Baxa, Ulrich
Lee, Kelly K
Mascola, John R
Graham, Barney S
Kwong, Peter D
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1330880
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1330880
Other Identifiers
ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/nsmb.3267
