Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators
Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators
About this item
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Author / Creator
Huang, Xin , Shaffer, Paul L , Ayube, Shawn , Bregman, Howard , Chen, Hao , Lehto, Sonya G , Luther, Jason A , Matson, David J , McDonough, Stefan I , Michelsen, Klaus , Plant, Matthew H , Schneider, Stephen , Simard, Jeffrey R , Teffera, Yohannes , Yi, Shuyan , Zhang, Maosheng , DiMauro, Erin F , Gingras, Jacinthe and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The structure of GlyRα3 in complex with a selective potentiator that decreases neuropathic pain in an animal model identifies a novel allosteric regulatory mechanism.
Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy, side effects and risk of addiction. Here, we present a novel class of potent selective...
Alternative Titles
Full title
Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators
Authors, Artists and Contributors
Author / Creator
Shaffer, Paul L
Ayube, Shawn
Bregman, Howard
Chen, Hao
Lehto, Sonya G
Luther, Jason A
Matson, David J
McDonough, Stefan I
Michelsen, Klaus
Plant, Matthew H
Schneider, Stephen
Simard, Jeffrey R
Teffera, Yohannes
Yi, Shuyan
Zhang, Maosheng
DiMauro, Erin F
Gingras, Jacinthe
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1349120
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1349120
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3329
