Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-complexity domain (LCD) is believed to be involved in both types of aggregation. To uncover the structural origins of these two modes of β-sheet-rich aggregation, we have determin...
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Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
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TN_cdi_osti_scitechconnect_1460868
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1460868
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-018-0064-2
