Identification of a cellularly active SIRT6 allosteric activator
Identification of a cellularly active SIRT6 allosteric activator
About this item
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Author / Creator
Huang, Zhimin , Zhao, Junxing , Deng, Wei , Chen, Yingyi , Shang, Jialin , Song, Kun , Zhang, Lu , Wang, Chengxiang , Lu, Shaoyong , Yang, Xiuyan , He, Bin , Min, Jinrong , Hu, Hao , Tan, Minjia , Xu, Jianrong , Zhang, Qiufen , Zhong, Jie , Sun, Xiaoxiang , Mao, Zhiyong , Lin, Houwen , Xiao, Mingzhe , Chin, Y Eugene , Jiang, Hualiang , Xu, Ying , Chen, Guoqiang , Zhang, Jian and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone H3
N
ε
-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has frequently been found to have low expression in various cancers. Here, we report the identification of MDL-800, a selective SIRT6 activator. MDL-800 increased the d...
Alternative Titles
Full title
Identification of a cellularly active SIRT6 allosteric activator
Authors, Artists and Contributors
Author / Creator
Zhao, Junxing
Deng, Wei
Chen, Yingyi
Shang, Jialin
Song, Kun
Zhang, Lu
Wang, Chengxiang
Lu, Shaoyong
Yang, Xiuyan
He, Bin
Min, Jinrong
Hu, Hao
Tan, Minjia
Xu, Jianrong
Zhang, Qiufen
Zhong, Jie
Sun, Xiaoxiang
Mao, Zhiyong
Lin, Houwen
Xiao, Mingzhe
Chin, Y Eugene
Jiang, Hualiang
Xu, Ying
Chen, Guoqiang
Zhang, Jian
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1499731
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1499731
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-018-0150-0
