Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link
Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases. 5-hydroxymethylcytosine binding, embryonic stem cell-specific protein (HMCES) recognizes and processes these lesions in the context of single-stranded DNA (ssDNA). A HMCES DNA-protein cross-link (DPC) intermediate is thought to shield the AP site from endon...
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Full title
Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link
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TN_cdi_osti_scitechconnect_1544876
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1544876
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-019-0255-5
