Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repe...
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs
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Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Murugan, Rajagopal , Scally, Stephen W. , Costa, Giulia , Mustafa, Ghulam , Thai, Elaine , Decker, Tizian , Bosch, Alexandre , Prieto, Katherine , Levashina, Elena A. , Julien, Jean-Philippe and Wardemann, Hedda
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The circumsporozoite protein of the human malaria parasite
Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in animal models. However, the limited efficacy of the PfCSP-based vaccine RTS,S calls for a better understanding of the mechanisms driving the development of the most poten...
Alternative Titles
Full title
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs
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TN_cdi_osti_scitechconnect_1644116
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1644116
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-020-0881-9
