Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
About this item
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Author / Creator
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States) , Van, Que N. , López, Cesar A. , Tonelli, Marco , Taylor, Troy , Niu, Ben , Stanley, Christopher B. , Bhowmik, Debsindhu , Tran, Timothy H. , Frank, Peter H. , Messing, Simon , Alexander, Patrick , Scott, Daniel , Ye, Xiaoying , Drew, Matt , Chertov, Oleg , Lösche, Mathias , Ramanathan, Arvind , Gross, Michael L. , Hengartner, Nicolas W. , Westler, William M. , Markley, John L. , Simanshu, Dhirendra K. , Nissley, Dwight V. , Gillette, William K. , Esposito, Dominic , McCormick, Frank , Gnanakaran, S. , Heinrich, Frank and Stephen, Andrew G.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The small GTPase KRAS is localized at the plasma membrane where it functions as a molecular switch, coupling extracellular growth factor stimulation to intracellular signaling networks. In this process, KRAS recruits effectors, such as RAF kinase, to the plasma membrane where they are activated by a series of complex molecular steps. Defining the m...
Alternative Titles
Full title
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
Authors, Artists and Contributors
Author / Creator
Van, Que N.
López, Cesar A.
Tonelli, Marco
Taylor, Troy
Niu, Ben
Stanley, Christopher B.
Bhowmik, Debsindhu
Tran, Timothy H.
Frank, Peter H.
Messing, Simon
Alexander, Patrick
Scott, Daniel
Ye, Xiaoying
Drew, Matt
Chertov, Oleg
Lösche, Mathias
Ramanathan, Arvind
Gross, Michael L.
Hengartner, Nicolas W.
Westler, William M.
Markley, John L.
Simanshu, Dhirendra K.
Nissley, Dwight V.
Gillette, William K.
Esposito, Dominic
McCormick, Frank
Gnanakaran, S.
Heinrich, Frank
Stephen, Andrew G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1735440
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1735440
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
