Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate...
Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography
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Author / Creator
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States) , Univ. of Wisconsin, Madison, WI (United States) , Pandey, Suraj , Calvey, George , Katz, Andrea M. , Malla, Tek Narsingh , Koua, Faisal H. M. , Martin-Garcia, Jose M. , Poudyal, Ishwor , Yang, Jay-How , Vakili, Mohammad , Yefanov, Oleksandr , Zielinski, Kara A. , Bajt, Sasa , Awel, Salah , Doerner, Katarina , Frank, Matthias , Gelisio, Luca , Jernigan, Rebecca , Kirkwood, Henry , Kloos, Marco , Koliyadu, Jayanath , Mariani, Valerio , Miller, Mitchell D. , Mills, Grant , Nelson, Garrett , Olmos, Jose L. , Sadri, Alireza , Sato, Tokushi , Tolstikova, Alexandra , Xu, Weijun , Ourmazd, Abbas , Spence, John C. H. , Schwander, Peter , Barty, Anton , Chapman, Henry N. , Fromme, Petra , Mancuso, Adrian P. , Phillips, George N. , Bean, Richard , Pollack, Lois and Schmidt, Marius
Publisher
United States: International Union of Crystallography
Journal title
Language
English
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Publication information
Publisher
United States: International Union of Crystallography
Subjects
More information
Scope and Contents
Contents
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is observed with near-atomic resolution using the most advanced X-ray source currently available: the European XFEL (EuXFEL). The high repetition rate of the EuXFEL combin...
Alternative Titles
Full title
Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography
Authors, Artists and Contributors
Author / Creator
Univ. of Wisconsin, Madison, WI (United States)
Pandey, Suraj
Calvey, George
Katz, Andrea M.
Malla, Tek Narsingh
Koua, Faisal H. M.
Martin-Garcia, Jose M.
Poudyal, Ishwor
Yang, Jay-How
Vakili, Mohammad
Yefanov, Oleksandr
Zielinski, Kara A.
Bajt, Sasa
Awel, Salah
Doerner, Katarina
Frank, Matthias
Gelisio, Luca
Jernigan, Rebecca
Kirkwood, Henry
Kloos, Marco
Koliyadu, Jayanath
Mariani, Valerio
Miller, Mitchell D.
Mills, Grant
Nelson, Garrett
Olmos, Jose L.
Sadri, Alireza
Sato, Tokushi
Tolstikova, Alexandra
Xu, Weijun
Ourmazd, Abbas
Spence, John C. H.
Schwander, Peter
Barty, Anton
Chapman, Henry N.
Fromme, Petra
Mancuso, Adrian P.
Phillips, George N.
Bean, Richard
Pollack, Lois
Schmidt, Marius
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Primary Identifiers
Record Identifier
TN_cdi_osti_scitechconnect_1904218
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_osti_scitechconnect_1904218
Other Identifiers
ISSN
2052-2525
E-ISSN
2052-2525
