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Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic respons...

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic respons...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289069812

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs

About this item

Full title

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs

Publisher

United States: Public Library of Science

Journal title

PloS one, 2013-01, Vol.8 (1), p.e54166

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of 13 antiepileptic drugs (AEDs) suppressed P...

Alternative Titles

Full title

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1289069812

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289069812

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0054166

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