Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic respons...
Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of 13 antiepileptic drugs (AEDs) suppressed P...
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Full title
Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs
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TN_cdi_plos_journals_1289069812
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289069812
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0054166
