Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control
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Author / Creator
Hersperger, Adam R , Pereyra, Florencia , Nason, Martha , Demers, Korey , Sheth, Prameet , Shin, Lucy Y , Kovacs, Colin M , Rodriguez, Benigno , Sieg, Scott F , Teixeira-Johnson, Leia , Gudonis, Debbie , Goepfert, Paul A , Lederman, Michael M , Frank, Ian , Makedonas, George , Kaul, Rupert , Walker, Bruce D and Betts, Michael R
Publisher
United States: Public Library of Science
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English
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Publisher
United States: Public Library of Science
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Contents
Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional correlates using ex vivo cells have been identified with the known ability to cause the direct elimination of HIV-infected cells. We have re...
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Full title
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control
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TN_cdi_plos_journals_1289075579
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289075579
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1000917
