Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt...
Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The origin, range, and structure of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD), are largely unknown. To investigate the molecular mechanism responsible for the broad phenotypic variability of sCJD, we analyzed the conformational characteristics of protease-sensitive and protease-resistant fractions...
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Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate
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TN_cdi_plos_journals_1289084497
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289084497
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002242
