Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific m...
Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
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Author / Creator
Vavricka, Christopher J , Li, Qing , Wu, Yan , Qi, Jianxun , Wang, Mingyang , Liu, Yue , Gao, Feng , Liu, Jun , Feng, Enguang , He, Jianhua , Wang, Jinfang , Liu, Hong , Jiang, Hualiang and Gao, George F
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation of novel NA inhibitors is of great interest. Recently, a highly potent NA inhibitor, laninamivir, has been approved...
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Full title
Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
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TN_cdi_plos_journals_1289089383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289089383
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002249
