AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo fol...
AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation against hemagglutinin domains...
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Full title
AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans
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TN_cdi_plos_journals_1289096266
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289096266
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002920
