Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc...
Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation
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Westaway, David , Genovesi, Sacha , Daude, Nathalie , Brown, Rebecca , Lau, Agnes , Lee, Inyoul , Mays, Charles E. , Coomaraswamy, Janaky , Canine, Brenda , Pitstick, Rose , Herbst, Allen , Yang, Jing , Ko, Kerry W. S. , Schmitt-Ulms, Gerold , DeArmond, Stephen J. , McKenzie, Debbie , Hood, Leroy and Carlson, George A.
Publisher
San Francisco: Public Library of Science
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English
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San Francisco: Public Library of Science
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Contents
During prion infections of the central nervous system (CNS) the cellular prion protein, PrPC, is templated to a conformationally distinct form, PrPSc. Recent studies have demonstrated that the Sprn gene encodes a GPI-linked glycoprotein Shadoo (Sho), which localizes to a similar membrane environment as PrPC and is reduced in the brains of rodents w...
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Full title
Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation
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TN_cdi_plos_journals_1289098410
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289098410
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002391
