Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures
Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Prions cause neurodegeneration in vivo, yet prion-infected cultured cells do not show cytotoxicity. This has hampered mechanistic studies of prion-induced neurodegeneration. Here we report that prion-infected cultured organotypic cerebellar slices (COCS) experienced progressive spongiform neurodegeneration closely reproducing prion disease, with th...
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Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures
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TN_cdi_plos_journals_1289104149
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289104149
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002985
