2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent me...
2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity exhibited attenuation in primary macrophages that was rescued in cells lacking Ifit1 gene expression. H...
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2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo
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TN_cdi_plos_journals_1289104197
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289104197
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002698
