Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations
Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the alpha site (109K [see text]H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that alpha-cleavage is important for PrP(C) physiology. To gain insights into the mechanisms of alpha-cleavage, we generated...
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Full title
Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations
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TN_cdi_plos_journals_1289259467
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289259467
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0009107
