Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish
Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens is enforced by Foxp3(+) regulatory T cells. Recombinatorial mechanisms also operate in teleosts, but active immunoregulation is thought to be...
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Full title
Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish
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TN_cdi_plos_journals_1289439880
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289439880
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0009478
