Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer
Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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We have previously described a RAF oncogene driven transgenic mouse model for non small cell lung cancer (NSCLC). Here we examine whether tumor initiation and growth requires the stem cell self-renewal factor Bmi1.
In order to evaluate Bmi1 function in NSCLC two founder lines that differ in incidence and latency of tumor formation were compared....
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Full title
Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer
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TN_cdi_plos_journals_1289670929
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289670929
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0004230
