Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated...
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease
About this item
Full title
Author / Creator
Koslowski, Maureen J , Kübler, Irmgard , Chamaillard, Mathias , Schaeffeler, Elke , Reinisch, Walter , Wang, Guoxing , Beisner, Julia , Teml, Alexander , Peyrin-Biroulet, Laurent , Winter, Stefan , Herrlinger, Klaus R , Rutgeerts, Paul , Vermeire, Séverine , Cooney, Rachel , Fellermann, Klaus , Jewell, Derek , Bevins, Charles L , Schwab, Matthias , Stange, Eduard F and Wehkamp, Jan
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differentiation, directly regulates the expression of HD-5 and -6, and was previously associated with the d...
Alternative Titles
Full title
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease
Authors, Artists and Contributors
Author / Creator
Kübler, Irmgard
Chamaillard, Mathias
Schaeffeler, Elke
Reinisch, Walter
Wang, Guoxing
Beisner, Julia
Teml, Alexander
Peyrin-Biroulet, Laurent
Winter, Stefan
Herrlinger, Klaus R
Rutgeerts, Paul
Vermeire, Séverine
Cooney, Rachel
Fellermann, Klaus
Jewell, Derek
Bevins, Charles L
Schwab, Matthias
Stange, Eduard F
Wehkamp, Jan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1289941673
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289941673
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0004496
