Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase In...
Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Deregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC) and this finding led to the development of tyrosine kinase inhibitors (TKIs) that are highly effective in a subset of NSCLC. Mutations of EGFR (mEGFR) and copy number gains (CNGs) of EGFR (gEGFR) and HER2 (gHER2) have been reported to predict for TKI response. Mutations...
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Full title
Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines
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TN_cdi_plos_journals_1289951801
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289951801
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0004576
