The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degra...
The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degradation
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
RecQ DNA helicases are critical for preserving genome integrity. Of the five RecQ family members identified in humans, only the Werner syndrome protein (WRN) possesses exonuclease activity. Loss of WRN causes the progeroid disorder Werner syndrome which is marked by cancer predisposition. Cellular evidence indicates that WRN disrupts potentially de...
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Full title
The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degradation
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TN_cdi_plos_journals_1290165826
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1290165826
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0004825
