The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize interferon signaling by binding host karyopherin α proteins, thereby preventing them from transporting...
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Full title
The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
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TN_cdi_plos_journals_1291061776
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1291061776
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002550
