Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel sus...
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
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Alzheimer's Disease Neuroimaging Initiative , for the Alzheimer's Disease Neuroimaging Initiative , Potkin, Steven G , Guffanti, Guia , Lakatos, Anita , Turner, Jessica A , Kruggel, Frithjof , Fallon, James H , Saykin, Andrew J , Orro, Alessandro , Lupoli, Sara , Salvi, Erika , Weiner, Michael and Macciardi, Fabio
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United States: Public Library of Science
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English
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United States: Public Library of Science
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With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown.
We completed a genome-wide association study on 381 participants in the ADNI (Alzheimer's Disease Neuroimaging Initiative) study. Samples were genotyped using the Illumina Human610-Quad BeadChip. 516,645 unique Single Nucleotide Polymorphisms (SNPs) were included in the analysis following quality control measures. The genotype data and raw genetic data are freely available for download (LONI, http://www.loni.ucla.edu/ADNI/Data/). Two analyses were completed: a standard case-control analysis, and a novel approach using hippocampal atrophy measured on MRI as an objectively defined, quantitative phenotype. A General Linear Model was applied to identify SNPs for which there was an interaction between the genotype and diagnosis on the quantitative trait. The case-control...
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Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
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TN_cdi_plos_journals_1291072865
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1291072865
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0006501
