A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in d...
A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Polycystin-1 (PC-1), the product of the PKD1 gene, mutated in the majority of cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD), is a very large (approximately 520 kDa) plasma membrane receptor localized in several subcellular compartments including cell-cell/matrix junctions as well as cilia. While heterologous over-expression systems...
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A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus
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TN_cdi_plos_journals_1292103616
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292103616
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0007137
