A vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice tra...
A vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice transgenic to multiple common HLA class II molecules
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Current HIV vaccine approaches are focused on immunogens encoding whole HIV antigenic proteins that mainly elicit cytotoxic CD8+ responses. Mounting evidence points toward a critical role for CD4+ T cells in the control of immunodeficiency virus replication, probably due to cognate help. Vaccine-induced CD4+ T cell responses might, therefore, have...
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Full title
A vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice transgenic to multiple common HLA class II molecules
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TN_cdi_plos_journals_1292194736
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292194736
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0011072
