Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints.
Fragment screening, structure guided des...
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Full title
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor
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TN_cdi_plos_journals_1292199081
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292199081
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0013123
