2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NA...
2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2 R172 in glioma patients. Genetic evidence indicates that these mutations share a common gain of...
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Full title
2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations
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TN_cdi_plos_journals_1292245270
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292245270
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0016812
