Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur t...
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
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Author / Creator
Soh, Junichi , Okumura, Naoki , Lockwood, William W , Yamamoto, Hiromasa , Shigematsu, Hisayuki , Zhang, Wei , Chari, Raj , Shames, David S , Tang, Ximing , MacAulay, Calum , Varella-Garcia, Marileila , Vooder, Tõnu , Wistuba, Ignacio I , Lam, Stephen , Brekken, Rolf , Toyooka, Shinichi , Minna, John D , Lam, Wan L and Gazdar, Adi F
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes.
We determined 1) mutational status, 2) copy number gains (CNGs) and 3) relative ratio betw...
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Full title
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
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TN_cdi_plos_journals_1292288888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292288888
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0007464
