Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements. Here we show mitochondrial ceramide elevation facilitates MOMP-mediated cytochrome c release in HeLa cells by generating a previously-unrecognized mitochondrial...
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Full title
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation
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TN_cdi_plos_journals_1304770912
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304770912
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0019783
