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Formalin fixation at low temperature better preserves nucleic acid integrity

Formalin fixation at low temperature better preserves nucleic acid integrity

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304770974

Formalin fixation at low temperature better preserves nucleic acid integrity

About this item

Full title

Formalin fixation at low temperature better preserves nucleic acid integrity

Publisher

United States: Public Library of Science

Journal title

PloS one, 2011-06, Vol.6 (6), p.e21043-e21043

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses during the interval between formalin penetration and tissue fixati...

Alternative Titles

Full title

Formalin fixation at low temperature better preserves nucleic acid integrity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1304770974

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304770974

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0021043

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