Formalin fixation at low temperature better preserves nucleic acid integrity
Formalin fixation at low temperature better preserves nucleic acid integrity
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses during the interval between formalin penetration and tissue fixati...
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Full title
Formalin fixation at low temperature better preserves nucleic acid integrity
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TN_cdi_plos_journals_1304770974
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304770974
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0021043
