Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of Axin is counteracted through relocalization of Axin protein to the Wnt receptor complex to allow for...
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Full title
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
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TN_cdi_plos_journals_1306360509
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1306360509
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0022595
