Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic...
Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Lnk plays a non-redundant role by negatively regulating cytokine signaling of TPO, SCF or EPO. Retroviral expression of Lnk has been shown to suppress hematopoietic leukemic cell proliferation indicating its therapeutic value in cancer therapy. However, retroviral gene delivery carries risks of insertional mutagenesis. To circumvent this undesired...
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Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis
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TN_cdi_plos_journals_1307377786
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1307377786
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0023640
