Identification of direct target engagement biomarkers for kinase-targeted therapeutics
Identification of direct target engagement biomarkers for kinase-targeted therapeutics
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Pharmacodynamic (PD) biomarkers are an increasingly valuable tool for decision-making and prioritization of lead compounds during preclinical and clinical studies as they link drug-target inhibition in cells with biological activity. They are of particular importance for novel, first-in-class mechanisms, where the ability of a targeted therapeutic...
Alternative Titles
Full title
Identification of direct target engagement biomarkers for kinase-targeted therapeutics
Authors, Artists and Contributors
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Record Identifier
TN_cdi_plos_journals_1310006411
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310006411
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0026459
