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Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potenti...

Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potenti...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310157696

Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs

About this item

Full title

Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs

Publisher

United States: Public Library of Science

Journal title

PloS one, 2011-11, Vol.6 (11), p.e27990

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The Prokineticin receptor (PKR) 1 and 2 subtypes are novel members of family A GPCRs, which exhibit an unusually high degree of sequence similarity. Prokineticins (PKs), their cognate ligands, are small secreted proteins of ∼80 amino acids; however, non-peptidic low-molecular weight antagonists have also been identified. PKs and their receptors pla...

Alternative Titles

Full title

Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1310157696

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310157696

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0027990

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