Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potenti...
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The Prokineticin receptor (PKR) 1 and 2 subtypes are novel members of family A GPCRs, which exhibit an unusually high degree of sequence similarity. Prokineticins (PKs), their cognate ligands, are small secreted proteins of ∼80 amino acids; however, non-peptidic low-molecular weight antagonists have also been identified. PKs and their receptors pla...
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Full title
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs
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TN_cdi_plos_journals_1310157696
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310157696
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0027990
