Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus
Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Mature microRNAs (miRNAs), derived through cleavage of pre-miRNAs by the Dicer1 enzyme, regulate protein expression in many cell-types including cells in the pancreatic islets of Langerhans. To investigate the importance of miRNAs in mouse insulin secreting β-cells, we have generated mice with a β-cells specific disruption of the Dicer1 gene using...
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Full title
Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus
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TN_cdi_plos_journals_1311198771
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1311198771
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0029166
