Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.
Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely used in human medicine as an antihypertensive drug. We isolated GA in a screen for drugs active in vivo ag...
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Full title
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions
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TN_cdi_plos_journals_1312186751
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312186751
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0001981
