Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human prim...
Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates
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Full title
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Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and food intake in mice, supporting the idea that TrkB is a key anorexigenic signal downstream of the me...
Alternative Titles
Full title
Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates
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Record Identifier
TN_cdi_plos_journals_1312202926
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312202926
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0001900
