Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs
Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs
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Author / Creator
Tribouillard-Tanvier, Déborah , Dos Reis, Suzana , Gug, Fabienne , Voisset, Cécile , Béringue, Vincent , Sabate, Raimon , Kikovska, Ema , Talarek, Nicolas , Bach, Stéphane , Huang, Chenhui , Desban, Nathalie , Saupe, Sven J , Supattapone, Surachai , Thuret, Jean-Yves , Chédin, Stéphane , Vilette, Didier , Galons, Hervé , Sanyal, Suparna and Blondel, Marc
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in several cell-based assays and in vivo in a mouse model for prion-based diseases.
Here we report the...
Alternative Titles
Full title
Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs
Authors, Artists and Contributors
Author / Creator
Dos Reis, Suzana
Gug, Fabienne
Voisset, Cécile
Béringue, Vincent
Sabate, Raimon
Kikovska, Ema
Talarek, Nicolas
Bach, Stéphane
Huang, Chenhui
Desban, Nathalie
Saupe, Sven J
Supattapone, Surachai
Thuret, Jean-Yves
Chédin, Stéphane
Vilette, Didier
Galons, Hervé
Sanyal, Suparna
Blondel, Marc
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1312287161
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312287161
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0002174
