Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment fo...
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases
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Author / Creator
GIANT Consortium , MAGIC , DIAGRAM Consortium , Perry, John R B , Voight, Benjamin F , Yengo, Loïc , Amin, Najaf , Dupuis, Josée , Ganser, Martha , Grallert, Harald , Navarro, Pau , Li, Man , Qi, Lu , Steinthorsdottir, Valgerdur , Scott, Robert A , Almgren, Peter , Arking, Dan E , Aulchenko, Yurii , Balkau, Beverley , Benediktsson, Rafn , Bergman, Richard N , Boerwinkle, Eric , Bonnycastle, Lori , Burtt, Noël P , Campbell, Harry , Charpentier, Guillaume , Collins, Francis S , Gieger, Christian , Green, Todd , Hadjadj, Samy , Hattersley, Andrew T , Herder, Christian , Hofman, Albert , Johnson, Andrew D , Kottgen, Anna , Kraft, Peter , Labrune, Yann , Langenberg, Claudia , Manning, Alisa K , Mohlke, Karen L , Morris, Andrew P , Oostra, Ben , Pankow, James , Petersen, Ann-Kristin , Pramstaller, Peter P , Prokopenko, Inga , Rathmann, Wolfgang , Rayner, William , Roden, Michael , Rudan, Igor , Rybin, Denis , Scott, Laura J , Sigurdsson, Gunnar , Sladek, Rob , Thorleifsson, Gudmar , Thorsteinsdottir, Unnur , Tuomilehto, Jaakko , Uitterlinden, Andre G , Vivequin, Sidonie , Weedon, Michael N , Wright, Alan F , Hu, Frank B , Illig, Thomas , Kao, Linda , Meigs, James B , Wilson, James F , Stefansson, Kari , van Duijn, Cornelia , Altschuler, David , Morris, Andrew D , Boehnke, Michael , McCarthy, Mark I , Froguel, Philippe , Palmer, Colin N A , Wareham, Nicholas J , Groop, Leif , Frayling, Timothy M and Cauchi, Stéphane
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m²) compared to obese cases (BMI≥30 Kg/m²). We performed two case-control g...
Alternative Titles
Full title
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases
Authors, Artists and Contributors
Author / Creator
MAGIC
DIAGRAM Consortium
Perry, John R B
Voight, Benjamin F
Yengo, Loïc
Amin, Najaf
Dupuis, Josée
Ganser, Martha
Grallert, Harald
Navarro, Pau
Li, Man
Qi, Lu
Steinthorsdottir, Valgerdur
Scott, Robert A
Almgren, Peter
Arking, Dan E
Aulchenko, Yurii
Balkau, Beverley
Benediktsson, Rafn
Bergman, Richard N
Boerwinkle, Eric
Bonnycastle, Lori
Burtt, Noël P
Campbell, Harry
Charpentier, Guillaume
Collins, Francis S
Gieger, Christian
Green, Todd
Hadjadj, Samy
Hattersley, Andrew T
Herder, Christian
Hofman, Albert
Johnson, Andrew D
Kottgen, Anna
Kraft, Peter
Labrune, Yann
Langenberg, Claudia
Manning, Alisa K
Mohlke, Karen L
Morris, Andrew P
Oostra, Ben
Pankow, James
Petersen, Ann-Kristin
Pramstaller, Peter P
Prokopenko, Inga
Rathmann, Wolfgang
Rayner, William
Roden, Michael
Rudan, Igor
Rybin, Denis
Scott, Laura J
Sigurdsson, Gunnar
Sladek, Rob
Thorleifsson, Gudmar
Thorsteinsdottir, Unnur
Tuomilehto, Jaakko
Uitterlinden, Andre G
Vivequin, Sidonie
Weedon, Michael N
Wright, Alan F
Hu, Frank B
Illig, Thomas
Kao, Linda
Meigs, James B
Wilson, James F
Stefansson, Kari
van Duijn, Cornelia
Altschuler, David
Morris, Andrew D
Boehnke, Michael
McCarthy, Mark I
Froguel, Philippe
Palmer, Colin N A
Wareham, Nicholas J
Groop, Leif
Frayling, Timothy M
Cauchi, Stéphane
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1313565012
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313565012
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002741
